Neurovirology and antiviral drug development (Philippe Plattet)
We aim at gaining a fundamental (mechanistic and structural) understanding of the cell entry and exit processes of two major pathogens belonging to the paramyxovirus family: measles virus (MeV), a human pathogen and canine distemper virus (CDV), an animal pathogen. Despite efficient vaccines, both viruses are still responsible of important global economic and health impacts. Although MeV and CDV induce severe immuno, respiro and brain pathologies, the frequency of brain disorders is far higher with CDV in animals than with MeV in humans. Thus, the goal of our investigations is to achieve sufficient knowledge to rationally design antiviral inhibitors with potent, tissue-independent, broad spectrum efficacy.